Why would I get fat?

Insulin resistance is a defense mechanism where the cells say there is too much electron pressure. The energy resistance principle approach to type 2 diabetes management is twofold: (1) increase flux by moving, (2) fasting. Fasting is probably the most underrated & the most underused intervention in medicine Nick Jikomes, PhD: "[…] What is insulin resistance in your view from an energy resistance perspective, and how do you think about it?" Martin Picard, PhD: "[…] Look at this energetically. What's happening? Why is the cell trying to block itself from being able to sense insulin? And then when insulin is stimulated, and the signaling axis is properly mobilized, you get glucose transporter that go to the cell membrane, and then the cell can take in glucose. That's the main point of insulin signaling. "The second interpretation you have that cells are trying to, this is an adaptation, and that adaptation likely is an anti-energy resistance defense mechanism. So insulin resistance is likely a defense mechanism where the cell says there's too much electron pressure. I'm being fed too many electrons, too much glucose, relative to what I can sustain with my mitochondria, and relative to the flux that is being demanded of me. Right? If a cell doesn't burn energy, like we said earlier, ATP is very high. The ATP synthase doesn't turn, the membrane potential is really high. The electrons have nowhere to flow. There's too much resistance. So that resistance propagates like it would in an electrical circuit, and then propagates upwards. Then the resistance manifests at the level of the cell's surface, the plasma membrane, by removing the transporters for glucose, which effectively increases resistance. "There's this beautiful paper from 2009. The title was, 'Insulin Resistance is an Antioxidant Defense Mechanism.' That's in PNAS. They were saying the reactive oxygen species that mitochondria spit out when there's excess energy resistance. It didn't use those terms, but they did the same kind of experiments I mentioned earlier where you feed mitochondria lots of electrons but you don't let them respire, you don't let them produce ATP, spit out tons of reactive oxygen species, and then they showed how this then propagates to the plasma membrane, and then the cell becomes insulin resistant. The pathology of insulin resistance starts in the mitochondria, somewhere along where the flow of electrons is not high enough to support the pressure. So it's a pressure to flow issue, and the core driver of pathogenesis is the system is overloaded." Nick Jikomes, PhD: "Right. The cell's saying, 'I can't handle all these electrons from all this glucose or whatever, so stop giving me so much.'" Martin Picard, PhD: "Exactly. So the insulin resistance really is the manifestation of a deeper seated energy resistance." Nick Jikomes, PhD: "So then from a therapeutic standpoint, you'd want to focus your attention on fixing the mitochondrial problem rather than trying to. . ." Martin Picard, PhD: "There's no mitochondrial problem." Nirosha Murugan, PhD: "Like a selective pressure problem of the flow of electrons." Nick Jikomes, PhD: "Yeah. The flow problem as opposed to trying to undo the insulin resistance." Martin Picard, PhD: "Yeah. And I've heard you know a couple clinicians who were reflecting on the use of insulin therapy in diabetes, because the standard of care nowadays, which is from a molecular perspective and how you started that question, there's an issue at the cell surface like insulin signaling is not happening. Let's restore, let's fix this, right? "And then one approach is to say the cells are insulin resistant to the effect of insulin, so let's give more insulin. Like that is the mindset that biomedicine is using to counter that problem. What this does at the cell level, you have the cell here, it says, 'Oh, the pressure of glucose, of electrons is so high. Let me protect myself.' And then the cell kind of finds some respite, probably in becoming insulin resistant. And then there's like 10× the amount of insulin that comes in and then it's overloaded. Then you start to damage your mitochondria. "There's some notion in diabetes management that giving insulin is useful at decreasing blood glucose. So HB1C goes down, but now peripheral organs starts to suffer, and there might be more nerve damage like neuropathy, and more of the other damage in some tissues that are insulin sensitive because you're forcing glucose into cells effectively that are trying to protect themselves. "So the energy resistance principle approach to disease management is twofold. Either you increase flux, right? How do you increase flux? You increase flux by moving. if you contract the muscles, that's going to increase the flux. You're going to breathe harder. So anything that kind of makes you breathe harder should be good to increase flux in the system. "Or the other approach is to the decrease the numerator, the energy potential, and you do that by eating less sugar, the source, the energy that we know insulin resistance. I don't know what the percentage is, more than half of people with diabetes, pre-diabetes, it is reversible. "Type 2 diabetes in many cases is completely reversible if you fast, and we know in normal healthy people you go through phases of more insulin resistance, and then insulin sensitive, and that's normal fluctuations with feed and fasting. If you fast for a day, or fast for two days, you become extremely insulin sensitive. Your tissues are like, 'OK, there's not too much pressure. Let me become receptive and sensitive to the influx of glucose.' I think fasting is probably the most underrated and the most underused therapy or intervention in medicine. So that's from first principles, ERP-based thinking, you can reduce the pressure by eating less, or eating less sugar, or you can increase flux by moving more. That's an ERP-like, first principles-informed strategy to addressing a medical issue in this case." Martin Picard, PhD & Nirosha Murugan, PhD with Nick Jikomes, PhD @ 01:39:34–01:46:00 (posted 2025-10-29) https://youtu.be/GiwDfsIgziA&t=5974

At the whole brain level there's a fixed energy budget. If something hyperactivates, it suppresses something else. If you chronically move the budget towards the salience & the threat network, then you're deactivating other parts of the brain that are involved in, say, creating attachment to others. Reshaping brain energy networks Martin Picard, PhD: "There are different large scale brain networks, like the mode network, the salience network, the ventral dorsal attention networks. There's this beautiful new paper from like two weeks ago, I think. Parker Kelley, who is a mitochondrial psychobiologist at UCSF, who does some work on psychedelics and mitochondria, he's come up with this beautiful ATP model which is about thinking energetically on how the brain manages energy. "And if you have a network, a neural network that's activated, this is maybe the way that the brain has to decrease energy resistance in one network. But to decrease energy resistance somewhere, you increase energy resistance somewhere else, right? So the way that the brain generates these complex energetic states, or complex energetic patterns that we see with fMRI, that we see with EEG, right, all of these modalities, they image energetic states of the brain. "Parker was thinking about this from an energy constraint perspective. And what we know is that at the whole brain level there's a fixed budget. The brain receives a certain amount of blood, so it has a certain energy budget. If it's going to hyperactivate something, it needs to suppress something else. There's always these kind of" Nirosha Murugan, PhD: "Push-pull dynamics." Martin Picard, PhD: "Push-pull dynamics, right? Something is turned off for something to be turned on. And you chronically turn something on, and you chronically turn something off, what happens is if you turn something off repeatedly, and you basically decrease blood flow and activation there, that thing is going to atrophy, the same if you put a cast over your arm or over your leg, that muscle is going to shrink. If you increase energy resistance, energy can't flow in that direction. If energy can't flow then that part is biologically means it's not useful. It shouldn't be sustained. There less transformation there, then you get catabolism, the breakdown of stuff. "The same thing could be happening in the brain. The brain has this budget, and if you chronically move the budget towards like the salience and the threat network then you're deactivating other parts of the brain that are involved in creating attachment to other human beings, or thinking positively about the world, about yourself, then those things atrophy. That's not a neurotransmitter-first process; this is an energetically driven process." Nirosha Murugan, PhD: "It explains why psychedelics have such a profound response, because you're redistributing that resistive network. So I think you have the brain energy network that people usually compute in neural networks, but then you can actually perhaps compute a resistive network, and therapeutics can basically modulate that resistance." Martin Picard, PhD: "Yeah, we could talk for a long time about psychedelics. But I wanted to ground this. The symptomatology and the ATP model is about psychopathology, and Parker's model about like energy being moving around in the brain and things being deprioritized, energetically deprioritized. You take the energy away from one network, and you put it towards like maybe the default network or the salience network. These energy dynamics are going to have a consequence on the hardware, eventually. This is a core tenet of the ERP. "The hardware, the physiology, the same way we talked about with exercise. If there's like high energy resistance and then you decrease it, now that's going to trigger some adaptive changes. But if energy resistance is always too high now at some point that thing is going to atrophy. So that could be happening in the brain, and those dynamics of energy resistance, like you get up in the morning, there's a spike of energy resistance and waking up is difficult for most people. It's a stressor and your heart rate increases, cortisol increases to sustain that, to raise that energy pressure so that you have the desire and the will to wake up and to live. But then when you never have this kind of lowering of energy resistance, that kind of yin and yang, or that push and pull, now things become set, and maybe psychopathology. "Like when not just you feel down for a day or two, but now you feel down all the time. This could be first and foremost the consequence of energetic disallocation. Your chronic reallocation of energy in one area and then you deprioritize something else and that thing ends up atrophying. Then that becomes a little fixed, and then it's really hard to get out of this rut. you that could be when when and how like neurally, ruts are created because of energetic forces, and then you become depressed, and you become schizophrenic, or you become bipolar. "Those are gradual processes and even though we think about them as really like rigid, and then people get these labels. I've seen people who receive these diagnostic labels. They were stuck in a rut, and then for through various ways, including ketogenic diet, they found a way to kind come out of this or with psychedelics and re-enlivened maybe part of their brain, move their energy in ways that they haven't been able to in a long time. So there's a deep layer of regulation there where the very rapid energy dynamics that happens at the level of energy resistance end up shaping the biology of the brain, and probably the level of synapses, neural networks, and so on." Martin Picard, PhD & Nirosha Murugan, PhD with Nick Jikomes, PhD @ 01:50:16–01:55:42 (posted 2025-10-29) https://youtu.be/GiwDfsIgziA&t=6616

Dance! Exercise is as good (if not better) in may cases than SSRIs, & dancing is the top modality. In most psychiatric disorders there's an energetic imbalance, which saps our will to exercise. However, moving increases the flux & reduces energy imbalance. In addition to increasing the flux at the cellular level, dancing increases the flux at the psychological level, too Nick Jikomes, PhD: "From this [Energy Resistance Principle] perspective, how would you guys start to think about something like a psychiatric illness, like depression, or something else that you think is illustrative?" Martin Picard, PhD: "Yeah, there's new evidence in depression. If you look at what proteins are upregulated, like what's happening physiologically, energetically, GDF15 is elevated in major depressive disorder, in other psychiatric disorders like schizophrenia and bipolar anorexia. So it seems increasingly clear that there's an energetic imbalance, dysregulation, in most psychiatric disorders. "There's a really nice work from a group at McLean Hospital in Boston where they've been imaging in the brain NADH / NAD ratio. Right? Like the first symptom or the first indication of reductive stress, and therefore energy resistance in the brain is that ratio, NADH and NAD, and energy resistance is elevated in the brains of people with severe mental illness. "And I suspect that's why some of the interventions, metabolic interventions like ketogenic diet, which seems to relieve symptoms and help the management of disease in many patients, not all, but many patients, that might be how it works. "And why exercise? […] If you have high energy resistance in your body, like the discomfort you have if you squat for too long your muscles start to burn, like imagine there's like 20% of that discomfort, but it's all the time in your body. And you feel terrible, right? It's like this ill-being, right? This like dis-ease, right? You're not at ease, ever. Like everything feels so painful. You don't want to exercise. You don't want to interact with other human beings. And so probably that energy resistance that we talked about diffuses through GDF15, maybe through other things, reaches the brain and makes you feel like shit. Exercising then is the last thing that you want to do. Despite this, there's really good evidence that moving, right, and maybe you moving is increasing flux in the equation, therefore reducing energy resistance. That improves symptoms across diagnostic categories. "And there's this cool meta analysis that was done recently showing that exercise, of course, is like at least as good (if not better) in many cases than SSRIs and other pharmacological treatments. And dancing, there's like one or two studies on like dancing was like the top anti-depressant modality in this meta analysis, and we can speculate as to why this would be the case, but for sure, dancing involves more flowing, more kind of increasing the flux, maybe not just at the cellular level, but psychologically, and there's like coordination, and other." Martin Picard, PhD & Nirosha Murugan, PhD with Nick Jikomes, PhD @ 01:46:03–01:48:54 (posted 2025-10-29) https://youtu.be/GiwDfsIgziA&t=6363

Diseases are adaptation to changes in energy resistance, e.g., cancer is an emergent phenomena of resistance changes accumulating over time. Energy resistance isn't a singular state; it's a dynamic state. Cure diseases by addressing the energy resistance changes instead of focusing on molecules like cytokines Nirosha Murugan, PhD: "I want to emphasize the adaptation to energy resistance, I think that will help ground this. I bring up cancer again because it is a problem that we really don't understand if we just look at it from mutations and p53 expression. "You mentioned that if you had high energy resistance chronically our bodies adapt. Our bodies are very good at adapting to inflammation, so if you had chronic inflammation, because there's resistance in our bodies from whatever we're doing, because of food sources or mutation increases, I think this is one way of looking at how resistance accumulates over time and causes emergent phenomena like cancer. So I think" Martin Picard, PhD: "this frames diseases as adaptation to" Nirosha Murugan, PhD: "energy resistance, right, or modulation of energy resistance. "And I think the biggest takeaway here is that energy resistance isn't a singular state; it's a dynamic state. If you view our physiology and the imprints that, we see which is cytokines molecules, hormones, whatever, and we just create therapeutics to modulate those imprints, then we're not going to really address a problem. We're just addressing the accumulation of that resistance. We're alleviating maybe temporarily, but it's not really getting the underlying cause of the energetic landscape. "And I think thinking about it this way also makes neural tech become more feasible. Thinking about complex processes like longevity, aging, that isn't a singular signature of molecules become realistic into how we understand it. "And then we can scale this to even something more abstract like consciousness as a flow of information, flow of energy resistance with and without our environment included becomes more realistic, and to having discussions around thinking it this way. "So I think understanding our system, our physiology, isn't just this molecular landscape, molecular machine, I think is where we started this conversation with, but as a flow of energy that's imprinted in a chemical signature is a good way of reframing how we think about our bodies." Martin Picard, PhD & Nirosha Murugan, PhD with Nick Jikomes, PhD @ 01:55:51–01:58:08 (posted 2025-10-29) https://youtu.be/GiwDfsIgziA&t=6951

Mitochondria are not powerhouse. Energy is neither created nor produced in mitochondria. Energy is transformed, always, through resistance. The analogy of mitochondria as a powerhouse is deeply misleading, and really restricts the spectrum of things you can consider Nick Jikomes, PhD: "So the energy is being transformed, as you said, Martin, it's not being created out of nowhere. Correct?" Martin Picard, PhD: "Yeah. We often, kind of in common parlance (and even in undergrad text) you'll see 'energy is produced.'" Nirosha Murugan, PhD: "Or 'created.'" Martin Picard, PhD: "Yeah. 'Energy is created, energy is produced in mitochondria.' Energy is not produced. Energy is not created. Energy is transformed, always, through resistance. "The analogy of mitochondria as a powerhouse is deeply misleading, because it simplifies this beautiful transformative organelle into like a unifunctional unit, like a little machine, which I think clouds this analogy. Analogies are so powerful, and they really restrict the spectrum of things you can consider, kind of entertain, once your mind is set on 'mitochondria are powerhouse.' "So I always encourage our trainees and anyone I get to talk to mitochondria about that that powerhouse analogy is really expired, and the more we continue using that term the more we do a disservice to the new, next generation of students and people who come into thinking about mitochondria." Martin Picard, PhD & Nirosha Murugan, PhD with Nick Jikomes, PhD @ 27:40–28:51 (posted 2025-10-29) https://youtu.be/GiwDfsIgziA&t=1660

"I used to believe that blue light was the big issue, but I think I would put polarized light on top. That's all the light that's man-made. I'd put blue light second, because there are some versions of blue light that are not damaging. […] Fire was the first non-native EMF light." — Dr. Jack Kruse --- Andreas David Christou: "Would you say that artificial blue light and non-native EMFs contributes to brain damage?" Dr. Jack Kruse: "It's the cause of brain damage, most of it. And I think it's the number one cause of all diseases. I think if you really wanted me to break it down, I used to believe that blue light was the big issue, but I think I would put polarized light on top. That's all the light that's man-made. I'd put blue light second, because there are some versions of blue light that are not damaging. […] "Fire was the first non-native EMF light. Why? People don't realize that fire is partially polarized, and we even have evolutionary proof that that light is enough to change us. Why? That's how Neanderthalss lost 125 grams of brain and we took over for them. So their brain shrunk and we showed up. But the real true part of this story that links to this Neanderthal story that people don't like to hear, people think all these new diseases, they call them Neolithic diseases, that's bullshit too. Why? Because all you have to do is go to Egypt and look at the King Tut exhibit and you'll see the mummies in the ground who lived inside with the fire versus the Nubians that were buried on the side of the Sphinx. The Nubians were perfect humans, perfect skulls, perfect dentition, thick outer and inner table of their bones. These were the guys that built the pyramid and the Sphinx. They were they were as healthy as healthy could be. We can tell from their fossils. And yet, when we x-ray King Tut and all the pharaohs, they have all the diseases that we have. "Remember, there was no power grid then. So, what does that tell you? How really important light is. And that light, fire light, is only partially polarized. So why did I tell you that I put polarized light above that? Because probably in the last 10 years, I realized that I was doing my tribe a disservice. "Even fire light from candles disrupts melatonin. It's not very much, but it does it. And if it does it, that means it can start this process of unraveling the evolution of what happened on the inner mitochondrial membrane. And I think people need to know that. "It's the same reason why I don't do affiliate marketing for red light guys. Why? Yeah, it's good, it's better than the LED lights. But remember, most of the red lights you have, they're all polarized. So, are you really doing yourself a favor? The answer is no. So, why do you always see on Twitter when people ask me what's the best red light? I always put Sun is TINA. What does TINA stand for? There Is No Alternative." Dr. Jack Kruse with Andreas David Christou @ 01:27:44–01:30:33 (posted 2026-03-01) https://youtu.be/tg9c6shuazI&t=5264

A 70kg adult needs to make on average 85 kg of ATP per day. Food only provides 1/3 of the amount of electrons to make ATP. The other 2/3 is supposed to be provided by sunlight Dr. Jack Kruse: "What people functionally do not realize is if they look at a chloroplast and they look at mitochondria, they're exactly the same, meaning that they were both once bacteria, what we consider endosymbionts. In other words, we took them and we change their function to be an energy producer. Now what people don't understand in animals is that, on average, and I'm giving you average human being, a 70kg adult, needs on average to make 85 kg of ATP per day. So I want you to think about that for a minute. If you have to make more ATP per day than you weigh, that is the function of a mitochondria. "But here is where it gets really interesting. Food only provides 1/3 of the amount of electrons to make ATP. Well, guess what is supposed to provide the other 2/3? Sunlight. And how does that happen? It's a function of the protein in the inner mitochondrial membrane called cytochrome C oxidase, which I think most people know. And cytochrome C oxidase is a heme protein, just like hemoglobin in our skin, and what it does is it absorbs best in what we call the optical window, and the optical window goes from about 700–1400 nm, specifically in the red and near infrared range. And what does it do? It makes ATPase spin much faster and we create several things from that. Not only do we create ATP, we create the other 2/3 of the ATP that food don't provide us. "The other key thing is the faster the ATPase spins, the higher magnetic flux we create in a cell. And that's where magnetic fields come. And most people who are in the allopathic and functional medicine don't functionally really understand how the magnetic field is generated, and how it's designed to alter as current that comes across the inner mitochondrial membrane in the form of electrons. And all food, in fact, everything in the environment, everything, functionally comes down to electrons." Dr. Jack Kruse with Dr. Justin Marchegiani @ 03:01–05:28 (posted 2017-04-21) https://youtu.be/Z_FD-ehf3Vs&t=181

You can never get well in the same environment that you got sick in until you realize that that's what you need to change. Odds are the defect is not in you Dr. Jack Kruse: "The mitochondriac perspective is all quantum living systems the defect isn't in them and I'll tell you the reason why I say that because that also is not an absolute truth but I can explain it. Most of the diseases that were afflicted by today or mitochondria based. Doug Wallace said […] that maybe 80% of diseases are mitochondrial or 20% are genetic. […] I believe it's only 5% are genetically based and 95% our mitochondria based. […] "The more we learn about mitochondria, the more clear it becomes that modern health care is focused in on the wrong genome. We focused on the nuclear genome because of Watson and Crick. But it turns out that we forgot the one that changes the most is the mitochondrial genome, and it's the one that responds most to the environment. "So this is the reason why the mitochondriac perspective is when you get sick the first thing you should do is don't look within; look outside in your environment and see what it is in your environment that has changed the power density relationship to your mitochondrial biology. And if you do that you're going to be far more effective then you will be if you have to rely on an expert functional medicine doctor or allopathic doctor. "The reason I point this out is I have so many people that come to me as new members, and they want to talk about their labs they just got done. […] I'm like stop for a minute. That testing absolutely tells you nothing about what's going on inside you. It says more about what was going on your environment the day you had it tested. And then it gets even crazier. If that lab was put on an airplane and sent through the mail it's affected by the environment until it got to the lab where it was deciphered. So is it really accurate on what is going on in you right now? The answer is when you really understand the quantum mechanisms in a mitochondria, they happen on an instantaneous basis. […] Justin Stellman: "So what you're talking about is you're never going to heal in the same environment that you got sick in […]" Dr. Jack Kruse: "Absolutely. I hope you say that again and again and again: You can never get well in the same environment that you got sick in until you realize that that's what you need to change. In other words, before you spend any money on any lab from an allopathic doctor or a functional medicine doctor, the number one thing you should spend money on is go hire yourself a non-native EMF engineer, rent their gear, and find out what the milligauss is in your car, your house, where you sleep, where you work, where you spend most of your time. Then begin to make changes, and then see how things change." Dr. Jack Kruse with Justin Stellman @ 45:41–48:20, 57:13–58:02 (posted 2018-08-07) https://youtu.be/kSek0e4RCwI&t=2741

Carbohydrates in season, when it's spring and summer, are perfectly fine for most people to eat. The problem is none of us protect ourselves from the damaging effects of blue light, and the more blue light you have the less carbohydrates you can eat Dr. Jack Kruse: "Blue light is the reason why people have this bad connotation to carbohydrates. A lot of people believe that carbohydrates are fundamentally bad. […] This is a half-truth; it's not true at all. Carbohydrates in season, when it's spring and summer, are perfectly fine for most people to eat. The problem is none of us protect ourselves from the damaging effects of blue light, and the more blue light you have the less carbohydrates you can eat. Why? Because this causes mitochondrial damage, and once the mitochondrial damage is present you can't handle carbohydrates anymore. But what do we do because we don't understand how mitochondria work? We immediately use linear relationships and blame the food, when it's really not the food at all; it's the light was behind it, 100%. […] "The seasonal approach, the easiest way for you to deal with it in your local environment is to sit down with a farmer in your area and say, 'Hey look, can you tell me what grows this time of the year, that time of the year, that time of the year,' and that's what you focus in on. […] "I advocate people eat locally, because guess what? You will get in a lot less trouble once you really know what's growing locally from your farmers." Dr. Jack Kruse with Justin Stellman @ 30:18–31:07, 33:00–33:16 & 39:51–40:02 (posted 2018-08-07) https://youtu.be/kSek0e4RCwI&t=1818

Dr. Jack Kruse: "The truth is an approximation of what we currently believe. So that means the truth is never absolute." Dr. Jack Kruse with npub15vzuezfxscdamew8rwakl5u5hdxw5mh47huxgq4jf879e6cvugsqjck4um @ 02:10:12–02:10:18 (posted 2025-01-03) https://youtu.be/mYMUiOMkKMM&t=7812

Prehistoric humans used tools to extract ketogenic, low-deuterium bone marrow. Our natural metabolic state is ketosis. Eat grass-fed animal fats. We adopted agriculture and chronic diseases appeared on a mass scale Dr. László Boros: "Four million years ago, and this was a big finding for me, papers that published that actually the prehistoric man was able to open the skull of large plant-eating animals and start eating bone marrow fat. That's what humans were eating and consuming for themselves for millions of years. […] These prehistoric men were able to go in a ketogenic, deuterium-depleted diet which provides nutritional ketosis and metabolic ketosis with low deuterium. […] They were able to develop brain skills, fine motor movements, fine kind of hand speech. They were able to use their body in a low-deuterium environment in a more flexible, more expressive, and in a more complicated complex way, as far as memory, as far as communications, as far as social behaviors, and so on. And that was all dependent on low-fat, ketogenic diets that they were obtaining from large, plant-eating animals carcasses. "Now, the other advantage of this is that they didn't have to chase, they didn't have to hunt, they didn't have to be exposed to predatory animals by competing for these preys. They just waited until the predators left, and the scavengers left, and the bones were kind of cleaned up for them just to break through those bones using stone tools. That's what they found in this Ethiopian land where they found these 3.8 to 4 million years old bone structures of large plant-eating animals that were actually broken into using tools. "So if you look at for example a mammoth, or if you look at like large plant-eating animals, they have about 20 kg of bone marrow in any of those big bones. So those were actually very reliable, good untouched food sources; they just had to learn how to use tools to get to this ketogenic, low deuterium fat source. […] "So as our natural metabolic profile is ketosis, they could maintain ketosis during the day, low deuterium ketosis, this is what we should do, by the way, this is our natural metabolic state. […] "Agriculture came along about 10,000 years ago, and they started cultivating plants that are higher in deuterium. They formed larger communities and they started harvesting and eating plants, and that's where chronic diseases, and that's where diseases appeared in mass scales as we know. And this is when infectious diseases appeared also, because infectious diseases also depend on deuterium for the propagation of infectious agents. And changing dieting behaviors changed the disease landscape on mankind and societies, and we ended up where we are now. "Most people eat processed food, and if you look at the kind of the general health or the chronic disease epidemics taking place on this entire planet you can tell there is a huge devastating change, and practically it's because of the environmental exposure and also the food. The food industry does not measure deuterium, they don't really label the deuterium, and they don't really care about deuterium, meaning that practically you're left alone, you have to figure out yourself where to find low deuterium food source, and those are grass-fed animal fat, practically." Dr. László Boros with npub1yd2h2lrwchshvm46jq7auh65tjkxmgnapkavh7tjtqq07kknupxsa980tv @ 59:34–01:05:26 (posted 2023-11-28) https://youtu.be/U6nw_3m_k74&t=3574

The safest water is what you eat, not what you drink. Your body makes the safest water for you. It actually makes you live free of the establishment Tristan Scott: "The deuterium-depleted water, it is accessible for people. I know they have as low as, I don't know if it's 10 or 20 ppm, and you can use that to mix to like 100, 120, maybe 130. Is that something you advocate for the everyday person trying to be healthier if they can't get, let's say, a lower deuterium-content water? Or do you really only see that as kind of a medical intervention for those say with cancer or with a serious issue?" Dr. László Boros: "Yeah, there are therapeutic applications below 100 ppm." Tristan Scott: "OK." Dr. László Boros: "Yeah, for those you need to go to a integrative setting, and you need to talk to doctors who are familiar with this deuterium story. "And for that matter, it's practically just a lifestyle. The safest water is what you eat, is not what you drink. Your body makes the safest water for you. How to deplete water the easiest? Just eat grass-fed animal fat. I get a lot of questions like, 'Is rainwater? Can I set up my own deuterium-depleting machine? Can I do this? Can I do that?' I'm like, 'Listen, no. Just go to the grass-fed food store, get some fat, and that's your fastest water. So you don't have to buy anything. Just eat. . ." Tristan Scott: "It's cheaper, too. Yeah." Dr. László Boros: "It's much cheaper. It actually makes you live free of this establishment. You don't have to go to doctors, you don't have to go to clothing stores, you don't have to buy medicines, you don't have to spend time in doctor's offices, you don't have to drive there, you don't have to pay. It's much cheaper after all, if you just look at this whole scenario." Tristan Scott: "That initial investment for that low time preference. But yeah, that's fantastic." Dr. László Boros with npub1yd2h2lrwchshvm46jq7auh65tjkxmgnapkavh7tjtqq07kknupxsa980tv @ 01:40:30–01:42:31 (posted 2023-11-28) https://youtu.be/U6nw_3m_k74&t=6030

Your deuterium load is determined by the ratio of carbohydrates vs. fat in your food, along with the deuterium content of the water. Eat at least 50, 60% fat from grass-fed butter, tallow, ghee, or fat, the rest from proteins, and very little carbs Tristan Scott: "If I eat a piece of grass-fed meat that's like 130 ppm, is it just going to produce like 130 ppm metabolic water, or is there kind of a variation? […]" Dr. László Boros: "So what you want to eat is the fat part fatty meat at least 50, 60% fat content, and the rest is proteins and very little carbohydrates. In the 118, 110 ppm range, that's the grass-fed natural butter and so on. Gábor's paper have this data. That's what can actually supply deuterium-free metabolic water in your mitochondrial matrix, because your glycolysis and your biochemical reactions can get rid of this much of deuterium, 118 ppm. I'm just giving you a number; it probably needs to be below 120 ppm. And grass-fed cow fat, tallow, ghee, those are in the 110, 100 ppm range. "So from this grass-fed, natural fat source you can produce deuterium free or very low deuterium, a few ppm matrix water, because your body has glycolysis and isomerases that can actually scavenge, that can actually get rid of deuterium from the fat-related intermediary metabolites, and also from carbohydrates somewhat. And because of these ratios, low carbohydrates are practically preventing deuterium to enter in your system. So it's not the deuterium content but how much of high and low deuterium containing substrates you consume. What's the ratio of carbohydrates vs. fat in your food? Practically, that determines your deuterium load, and what's the water deuterium content that you consume." Dr. László Boros with npub1yd2h2lrwchshvm46jq7auh65tjkxmgnapkavh7tjtqq07kknupxsa980tv @ 57:07–59:26 (posted 2023-11-28) https://youtu.be/U6nw_3m_k74&t=3427

"Every Thanksgiving, […] tell everybody what you want in case you become incapacitated. […] It's not fair to leave that to your family, your wife, your kids." The interface of death and money generates the strangest of human behaviors Dr. Jack Kruse: "[…] I look at the angiogram, and they were told that this guy needs to have four-vessel CABG, and I'm going. . ." Robert Breedlove: "Can you tell us what that is. It's a quadruple bypass?" Dr. Jack Kruse: "Quadruple bypass. He's 83 years old. […] If I'm 83 years old, and I have some angina, I'm like, give me nitroglycerin, and I'll adjust my lifestyle appropriately. I'll go sit on the top of my roof. But you're not fucking cutting my chest open. I don't care if my wife, my kids, and everybody in the world wants me to do it. I don't care care if I have the best cardiac surgeon telling me that I'm an idiot. There is no fucking way I'm doing that. And if I go out, I'm cool. I'm going out on my terms. […] "I counsel my patients, every Thanksgiving, since I'm an American, we sit down and instead of saying grace, you tell everybody what you want in case you become incapacitated. Why? Because it's not fair to leave that to your family, to your wife, your kids." Robert Breedlove: "It takes the emotion out of the decision, right?" Dr. Jack Kruse: "Well not only that, but they're also incentivized." Robert Breedlove: "Right, right, right, right, right." Dr. Jack Kruse: "They're incentivized. Incentives create outcomes, my friend. I mean, aren't we back to the same story?" Robert Breedlove: "The interface of death and money generates the strangest of human behaviors." Dr. Jack Kruse: "But you know, people don't think about these things. They don't think that this can happen to them." Robert Breedlove: "Yeah." Dr. Jack Kruse with npub15vzuezfxscdamew8rwakl5u5hdxw5mh47huxgq4jf879e6cvugsqjck4um @ 02:10:16–02:11:01 & 02:13:23–02:14:00 https://youtu.be/lhxca0ANvIk&t=7816

Chemically made supplements of methionine, melatonin, NAC, choline are not low deuterium. As such, they are harmful. Most of these supplements are chemically made. Biologically made methionine, NAC, melatonin, choline are low in deuterium Tristan Scott: "That's so fascinating in terms of the synthetic. I hate when a lot of these, maybe it's more the Fitness Bros, or the 'Show me the study' guys are like, 'Well, there's no difference between synthetic [methionine] and natural components.'" Dr. Stephanie Seneff: "That is not true." Tristan Scott: "Now it's like, 'Well, we have here some proof that actually there is.' Why is there actually a difference? Is it just because they don't consider those deuterium-depletion steps that our innate biology has built in?" Dr. Stephanie Seneff: "Precisely, yeah. First of all I want to say that melatonin has the same problem. And N-acetylcysteine does, too. So the acetyl in N-acetylcysteine, that's going to be low deuterium if it comes from the gut microbes, but if it's made synthetically it won't. So if you're taking a supplement N-acetylcysteine, no guarantee that that acetyl is going to be low deuterium. "And melatonin, melatonin has both an acetyl and a methyl attached to it. It starts out as tryptophan, which of course comes out of the shikimate pathway. Tryptophan gets turned into serotonin, which is another neurotransmitter. And then serotonin gets turned into melatonin, and when you do that you add a methyl and an acetyl. Both of them are going to be low deuterium if they came from a biological source. "But if you eat a methionine that's made in the chemistry lab, which it typically is, that's how you can do it cheaply. […] Imagine growing microbes and having to purify the methionine that's in there with all the other stuff that's there, right? Or the melatonin. That's a lot of work. So you'd rather just make it chemically. You can get a pure supply more easily if you don't have to deal with all the biological life that might be mixed up in there and cause problems. So most of these supplements are chemically made, and they're not going to be good, so I don't recommend any of these supplements that are going to have these. "Choline is another one. Choline is going to be low deuterium if it comes from a biological source. But if they're making in the chemistry lab, forget it. It's not good for you. So I think people are loading up on supplements that are actually hurting them because they're not supplying the low deuterium resource that would have happened if it had been biological. "Now I need to explain why that's the case, because it's super fascinating. I figured it out based on a paper that was written in the 1960s. […] That paper showed […] that the gas that was made by these [gut] microbes, hydrogen gas, H₂, had 80% of the deuterium gone. It was down by a factor of five. 80% gone. So that becomes a really good source of low deuterium hydrogen. And then the microbes are very careful to make sure […]" Dr. Stephanie Seneff with npub1yd2h2lrwchshvm46jq7auh65tjkxmgnapkavh7tjtqq07kknupxsa980tv @ 58:17–01:01:20 (posted 2023-12-05) https://youtu.be/LaU2i0T5FWY&t=3497

Glyphosate damages gut microbiota, raises gut pH, damages acid-loving microbes' ability to make butyrate. The colonocytes lining the gut get sick from a lack of butyrate, which leads to IBD and eventually colon cancer Tristan Scott: "Yeah, I think it's incredible, and that's one of the main mechanisms or areas that people are pretty familiar with is that [glyphosate] is like a nuke for your gut, really. But when you get into how it works and then how something I realized is just how important the gut is for producing things like B vitamins. I think you said in your book that it augments the the dietary intake of it. So that's something that especially folks in the diet community pretty much never talk about, and that care we need to have for our microbiota and just how the diversity has been just decreasing tremendously over decades. If you look at like studies comparing the Hadza in Africa and Tanzania compared to the modern man, it's so crazy." Dr. Stephanie Seneff: "I think I talk about that in my book. I have a chapter on the gut which I've spent a long time on it. The gut is a hard problem when you start looking. The research literature has blossomed. There's tons of papers now, and they're very complex with all these pretty colors, and all these Venn diagrams, and all these different microbes in different amounts, and it's extremely overwhelming. But I eventually dug a story out of that I feel that I'm quite confident about which is super interesting. "Glyphosate causes the pH of the gut to go up, and I think that's because of these undigested peptides. Normally the proteins come in, they get broken down into the amino acids, they get absorbed in the midgut, they get absorbed into the system, and now everybody's happy, because you need those amino acids to make human proteins. "But they don't get digested. They end up in the lower gut still as peptide sequences. And then there's gut microbes there that can break them down, but break them down all the way, because you can no longer absorb those amino acids. They have to be broken down all the way to nitrogen, which is going to be ammonia, which is going to be a high pH. So you raise the pH of the gut, and then that causes the acid-loving microbes to get sick they can't really live in this high pH. Those are the ones that make the acetate, the butyrate, the propionate. These are short-chain fatty acids that are incredibly important for the host, because the colonocytes lining the gut, their main food is butyrate, and butyrate comes from these acid-loving bacteria. And so when they can't make the butyrate, the colonocytes get sick, and then you end up with inflammatory bowel disease and irritable bowel disease, and eventually you get you know colon cancer and things like that, all of which are going up dramatically in step with the rising glyphosate usage in this country." Dr. Stephanie Seneff with npub1yd2h2lrwchshvm46jq7auh65tjkxmgnapkavh7tjtqq07kknupxsa980tv @ 26:21–28:49 (posted 2023-12-05) https://youtu.be/LaU2i0T5FWY&t=1581

Every protein that's made starts with methionine. The 'methionine is bad for aging' study was flawed as it used synthetic high-deuterium methionine; the deuterium caused the harm. Cancer as a signal of mitochondria stealing methyls off of the DNA due to too much deuterium Tristan Scott: "I've listen to these biohackers. […] They eat animal based, they eat meat, but they would always be like, 'Well, there is one caveat. Methionine has been shown to be bad for aging […]'" Dr. Stephanie Seneff: "Can I talk about that there? Because I have a very good story for that." […] "I remember years ago reading about this methionine deficiency idea to try to live longer, and I was like, 'That is just so wild, so crazy. How can that possibly be true?' I was blown away by it. That just doesn't make any sense, because methionine is extremely important. It's like every protein that's made starts with methionine. It's how you start the protein synthesis. How could deficiency be a good thing? Just recently I had the idea because methionine of course is the source of methyl groups. This can get us into the deuterium big time." […] "It turns out the gut microbes are responsible for making this methyl CH₃, which has these three Hs that are not deuterium. They're like almost guaranteed not to be deuterium because of what the microbes do. So they become very important to the body, the CH₃ that's attached to the sulfur of the methionine amino acid. Then that CH₃ becomes the methyl groups that get distributed throughout your body, stuck onto your protein, stuck onto your DNA, your RNA. It's like thrown around everywhere in the body and they hold on to it. Then eventually it gets metabolized in place, like from the DNA, that methyl gets metabolized and turned into carbon dioxide and water within the mitochondria. "Those Hs get delivered to the mitochondria, Hs that are guaranteed not to be deuterium, and so that becomes very valuable to the body. It's actually storing all these methyls as a resource for when the mitochondria become toxic because they've got too much deuterium, they need to have a really good source of a guaranteed food that's going to be healthy, they can grab the methyls off the DNA. Eventually if they grab enough of them the DNA becomes deficient in methyls, and now you've got cancer, because that's how the clue for cancer, you know, many of the cancers are a consequence of hypomethylated DNA. The DNA has been losing its methyls, and that's like the cell is saying, 'Hey, my DNA is losing its methyls. We probably have a deuterium problem here.' It's like a signal that there's a deuterium problem, because it's had to steal the methyls from the DNA. "So they had this study on these rats and they fed them a synthetic diet. They were given amino acids that were produced in the laboratory. It was explained in the paper. So the rats were given all these equal appropriate amounts of all the different amino acids to eat. That's their food. It's very highly synthetic. It was made in the chemistry lab. So they gave the control group lots of methionine and then the treatment group low methionine. So that's your low methionine diet. They showed that the rats that got the low methionine diet lived longer and were healthier. So then they said, 'Well of course then methionine is bad.' Right? "The flaw is that that methionine that those rats ate was not guaranteed to have low deuterium in its methyl groups. It was made in a chemistry lab. So those methyl groups were not gold at all; they were just crap, so to speak. They were not healthy food. But on the other hand they had methionine so they weren't inspired to make methionine because it was already plenty. So they were basically misled into thinking that methionine was perfectly healthy, the way it would normally be if it had been made biologically. But because it was made in the chemistry lab it didn't have the low deuterium. So these rats are all saving all this methyl groups and being careful to keep track of them, but those methyls are no good, because they came from the synthetic laboratory instead of from a biological source." Dr. Stephanie Seneff with npub1yd2h2lrwchshvm46jq7auh65tjkxmgnapkavh7tjtqq07kknupxsa980tv @ 54:03–57:48 (posted 2023-12-05) https://youtu.be/LaU2i0T5FWY&t=3243

Drink only when you're thirsty, only as much water is necessary to kill your thirst. Water as an unpredictable source of deuterium. "If you don't know the deuterium content you have to limit the intake." Developing diabetes insipidus from excessive water drinking, making you even more thirsty Tristan Scott: "You said that you drink as little water as possible, and then when you do. . ." Dr. László Boros: "No. I only drink when I'm thirsty, […] and I drink as much as water is necessary to kill my thirst, and that's usually rain water below 125 PPM. It's very simple. […] It's deuterium depleted, but it's in the rain, kind of a good fall rain, 125 PPM or below. Tap water is 143 PPM to 155 PPM, most of the major cities. If it's coming from higher elevations, from for example the Colorado River, it may go down to 138 PPM. But it's still very high when you drink two or three liters of it a day. […] "I consider everything that you put in your body as a deuterium source, potentially. If you don't know the deuterium content you have to limit the intake. "The other problem is with excessive water drinking without salt is that osmolarity will drop in your blood. Osmolarity will drop in your brain cell, so you will actually have brain swelling that dismantles the hypophysis or the pituitary gland. It's actually locked into your sella turcica, which is a bony little compartment. That's where this organ, this pituitary gland, sits in. If you drink water excessively, this gland kind of expands in this bony capture, or it's capsizing this bony compartment called sella turcica […], and actually start compressing on ADH releasing cells, the antidiuretic hormone, and also sex hormone, and growth hormone, and thyroid hormone regulating cells, because they are all produced by the pituitary gland. So if those are swollen then your antidiuretic hormone is not helping you to preserve water, so you develop diabetes insipidus, and you have to drink more because you are more thirsty, simply because you are unable to salvage water through the actions of antidiuretic hormone, which prevents diuresis. It actually retains water from your primary filtrate in your kidneys, so you cannot regulate your own water homeostasis. "So you're actually exposed to an environmental, unpredictable deuterium source in the form of water. […] "Actually, you can actually die of water poison, you can die of brain swelling. […] Excessive water drinking without thirst is causing more harm that you can actually imagine. […] Your body has your thirst or any other natural signal. For example, if you're hungry you eat, if you're tired then you sleep, if you're thirsty then you drink. […] "Actually if you drink excessively, like let's say a liter of water half an hour, you're going to pee out 1.3 liters of water in the next four hours for sure, but it's gone in the next two hours practically. So it's useless. Your body is trying to get rid of it simply because it didn't need it. So you are constantly challenging your body to kind of overcome your behavioral patterns simply that are physiologically, biochemically totally against your own regulatory systems. Those are overdriven by media, by advertisements, and the list just goes on and on. That's our scientific position on this whole issue." […] "If you're thirsty, drink as much as is necessary. When we were kids we went out on these school trips, and I remember teachers telling us when we were like, 'Oh, I'm thirsty. I'm thirsty,' they said, 'Just don't drink. Don't drink. If you're still thirsty in five minutes, wait five minutes,'" Tristan: [laughs] Dr. László Boros: "'then you get one little sip. That's it.' And actually it was sufficient. Well, we were lean. We were not like as obese as nowadays these kids, unfortunately." Dr. László Boros with npub1yd2h2lrwchshvm46jq7auh65tjkxmgnapkavh7tjtqq07kknupxsa980tv @ 01:29:12–01:30:14, 01:31:40–01:36:26 & 01:37:33–01:38:12 (posted 2023-11-28) https://youtu.be/U6nw_3m_k74&t=5352

Deuterium content of grain-fed sour cream or butter is higher than grass-fed by 26 PPM. Higher deuterium contributes to the chronic disease epidemic Dr. László Boros: "So we wrote a paper about this in Metabolomics which compares the metabolic and the disease state of the grass-fed and the grain-fed cows based on published data in the literature. It's in Metabolomics so if you want to read more about it." Tristan Scott: "That's the 'What to feed or what not to feed,' right?" Dr. László Boros: "Exactly. 'What to feed or what not to feed.'" Tristan Scott: "Yeah, yeah. I read that." […] Tristan Scott: "I had to ask the dairy question […]" Dr. László Boros: "Yeah of course. Very critical, very important question." Tristan Scott: "But it makes sense, right? If you have to grow obviously, I would imagine the deuterium content would be pretty high in some those. . . Dr. László Boros: "Yeah, yeah. We measure those. From your perspective, if you compare sour cream or butter from grass-fed cows compared to grain-fat cows if you compare to those. . ." Tristan Scott: "What, a 15 PPM difference? 20?" Dr. László Boros: "So you go from 110 to 136." Tristan Scott: "Wow." Dr. László Boros: "So yeah." Tristan Scott: "26. Wow. That's incredible." Dr. László Boros: "26 PPM. Yes. Listen, it's not a joke. I mean it's not just something just to walk by and say, 'Oh well, whatever.' It is significant and when it comes to human health and animal health, or just planetary health, or just practically chronic disease epidemics you have to take these into consideration unfortunately." Tristan Scott: "Yeah. 100%." Dr. László Boros with npub1yd2h2lrwchshvm46jq7auh65tjkxmgnapkavh7tjtqq07kknupxsa980tv @ 01:26:23–01:28:09 (posted 2023-11-28) https://youtu.be/U6nw_3m_k74&t=5183

Nucleic acid (DNA or RNA) persisting for weeks. Tremendous dose getting through breast milk. Spike persisting almost a year later. Five peer-reviewed studies show that the DNA contamination is found in patients Kevin McKernan: "Why do we care about this so much? Well, there's all of these papers that have rolled out demonstrating nucleic acid persistence, and I say nucleic acid because we don't know from these papers whether they're measuring DNA or RNA. They used a method known as RT-PCR which which amplifies both. And so many of these papers published before this DNA contamination was known, so they assumed it was the RNA because they were looking at the spike sequence. But if they went back, and tortured that with perhaps primers that looked at the plasmid backbone that's not supposed to be in the vaccine, I'm kind of curious what they would find. "But we have the Krauson paper here that was finding this, what are they, they are out 30 days in heart tissues. There's the Röltgen‬ paper which is out 60 days. "There are all these other papers that found it in placenta two to 10 days [Veronica J. Gonzalez, et. al]. There was found in plasmid from Castruita paper 28 days later in plasma. And then in breast milk there was, this was out to about five days in the Hannah paper. "And the Hannah paper is undermeasuring this. They have a PCR assay that's horribly insensitive; it only has about a 400,000 copy LOD (limit of detection). That should be down at around 10 copies. So their assay for some reason is insensitive to this issue, so I think if they had a more sensitive assay they would have found this out 10, 15 days in breast milk. "Anyway, there's a tremendous dose getting through breast milk. If you add up what's in that paper, the number of feedings that a child has, this is not an insignificant amount as those authors suggest, because they did not consider how much milk a baby drinks over the course of three days, and that would add up to a substantial and sizable dose that that child was getting in that feeding. "Now, very recently, we're also seeing spike protein persistence in these two papers. […] The Yale study actually found it 709 days out, and the Patterson study found it 245 days out. But this is protein that is not going away in 48 hours; it is there almost years later. Why is that? Proteins don't do that. Most proteins have a turnover rate that's in weeks, not years. So this implies something is regenerating the spike protein in your body, or it is evading destruction for long periods of time and certain what reservoirs in the human body. So this leads people to believe perhaps this mRNA is lasting longer, or there's plasmids in there still generating spike, and we don't know the answer to that yet. "So now here's the real kicker that I haven't presented on much lately, because this is very recent work. The kicker here is that we're now finding these sequences not just in the vaccine, but we're finding it in people. Now we don't know if it's integrated but it's there. And these are studies that weren't looking for it and the methods they used arguably suppressed the signal significantly. All right, so there's at least five peer-reviewed studies that have come out looking at RNA sequencing of people who were vaccinated, unvaccinated. And if you dig through that data that's in NCBI, you can take all those reads, map them against the plasmids from the vaccine manufacturers, and you can find that DNA in these patients." npub1k8dxqxgnv2p6ymwkamfrx237qjct3zezsx2xevt6z6nzdgalff3qy94qte @ 25:03–28:29 (posted 2025-06-10) https://rumble.com/v6uhd1d-presentation-to-new-zealand-co…