Butyrate is the primary fuel source for colonocytes (not glucose). If you lose your butyrate producers (faecalibacterium, roseburia) → colonocytes lose their preferred fuel → ↓ mito function → ↓ decreased oxygen utilization → ↑ luminal oxygen → obligate anaerobes die off & facultative anaerobes like e. coli expand = dysbiosis BUT those were the bacteria making the butyrate in the first place so its actually a vicious cycle once this self-regulating system loses its tensegrity. So in order to fix the microbiome you gotta fix colonocyte energy production and O2 utilization.