I have a pinephone, and although is it underpowered and a bit slow, it still works well. I use PostmarketOS with phosh interface. The only main issues I've had is running apps on the small screen. The bit I really like is being able to plug it into and HDMI screen, mouse & keyboard, use it like a proper desktop. Using QubesOS would require far more power then is currently available, I think, happy to be wrong though 😃