Bip 110 would have the effect of putting spam into the UTXO set, harming node decentralisation, and the strict relay policy of Knots would centralise mining by encouraging miners to use out-of-band systems. It's an attack on all the important aspects of decentralisation, including Luke's desperate attempt to make himself the lead developer
This debate ended in early 2024 when, in response to Mara's Slipstream, the bitcoin network (without asking permission from Core or Knots) relaxed relay policy in order to defend mining decentralisation