creatine use for nicotine cessation: Only have anecdotal evidence to support this in a handful of people who were all hooked on zyn pouches Smokers had lower concentrations creatine in the medial prefrontal cortex compared to nonsmokers https://pubmed.ncbi.nlm.nih.gov/33274546/ https://www.nature.com/articles/s41380-023-02247-0 creatine supplementation increases brain levels https://link.springer.com/article/10.1007/s40279-023-01870-9 nicotine lowers brain creatine → low brain creatine may impair prefrontal function and self-regulation → creatine supplementation might restore those levels and support cognitive function during withdrawal